Postinjury Inflammation and Organ Dysfunction

Multiple organ dysfunction during resuscitation is not postinjury multiple organ failure.

HYPOTHESIS Multiple organ dysfunction (MOD) within 48 hours of injury is a reversible physiologic response to tissue injury and resuscitation. DESIGN A prospective 10-year inception cohort study ending September 2003. SETTING Regional academic level I trauma center. PATIENTS One thousand two hundred seventy-seven consecutive trauma patients at risk for postinjury multiple organ failure (M...

Persistent Inflammation, Immunosuppression, and Catabolism: Evolution of Multiple Organ Dysfunction.

BACKGROUND Multiple organ dysfunction (MOD) has plagued intensive care units (ICUs) for more than four decades, and its epidemiology has evolved because more patients are surviving previously lethal insults. Over the years, different predominant phenotypes of MOD have been described, all of which have consumed tremendous healthcare resources and have been associated with prolonged ICU stays and...

Inflammation, coagulopathy, and the pathogenesis of multiple organ dysfunction syndrome.

OBJECTIVE An improved understanding of the mechanisms through which infecting pathogens harm the host is leading to new formulations of the concept of sepsis. We review the roles of inflammation and coagulation in the pathogenesis of the multiple organ dysfunction syndrome, and explore the potential of new therapies to restore the fine biological balance between procoagulant and anticoagulant m...

Endothelial Dysfunction and Inflammation

Scoring organ dysfunction.

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